ChemSusChem (2022): “Biocatalytic production of a Nylon 6 precursor from caprolactone in continuous flow”
Nature Chemistry (2022): “Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses”
ChemBioChem (2022): “Stereo-divergent enzyme cascades to convert racemic 4-phenyl-2-butanol into either (S)- or (R)- corresponding chiral amine”
ChemBioChem (2022): “Stereo-divergent enzyme cascades to convert racemic 4-phenyl-2-butanol into either (S)- or (R)- corresponding chiral amine” The synthesis of enantiopure chiral amines from racemic alcohols is a key transformation in the chemical industry, e. g., in the production of active pharmaceutical ingredients (APIs). However, this reaction remains challenging. In this work, we propose a one-pot […]
Scientific Reports (2022): “High-throughput screening methods for enzyme-mediated alcohol oxidation”
Scientific Reports (2022): “High-throughput screening methods for enzyme-mediated alcohol oxidation” Alcohol oxidation for the generation of carbonyl groups, is an essential reaction for the preparation of fine chemicals. Although a number of chemical procedures have been reported, biocatalysis is a promising alternative for more sustainable and selective processes. To speed up the discovery of novel […]
ChemSusChem (2022): “Sustainable (flow)synthesis of antiviral and anticancer nucleosides by a novel purine nucleoside phosphorylase reversibly immobilized”
Chemistry- A European Journal (2021): “GPhos ligand enables the production of chiral N-arylamines in a telescoped transaminase–Buchwald-Hartwig amination cascade in the presence of excess amine donor”
A fine paper from Chris. Here he explored how we can combine transaminases and chemocatalysis, specifically looking for water-compatible Pd catalysts to synthesise arylamines. All the credits goes to him and he shares here the corresponding authorship! Chemistry- A European Journal 2021 in press (doi:10.1002/chem.202103472) Read the full paper here Related Posts
Chem Comm (2021): “Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity”
Another collaborative paper with the group of Martin Albrecht here at the DCBP, we really like to combine carbenes and natural molecules such as peptides and check out how the catalysis is affected. Matteo worked on the synthesis and David did his usual magic with molecular dynamics and simulations! A great paper to read! Chemical Communication 2021, 57, 9068 – 9071 […]
Green Chemistry (2021): “Biocatalytic access to betazole by one-pot multienzymatic system in continuous flow”
Maria successfully tackled a multi enzyme system which requires a NOX enzyme to recycle the NADH cofactor. Not a small battle when you require to maximise the air/oxygen content in a sealed system like a flow reactor. Very proud of this work! Abstract: “As an alternative to classical synthetic approaches for the production of betazole drug, a […]
ACS Sustainable Chemistry and Engineering (2021): ” Enantio-complementary continuous-flow synthesis of 2-aminobutane using covalently immobilized transaminases”
Amazing work with our collaborator Dr. Beatriz Domingues in Johnson Matthey. Chris engineered our evergreen HeWT to make it enantioselective in the synthesis of the smallest chiral amine, 2 amino butane. Well done! You can find the paper here Related Posts
J Biotech (2021): “Producing natural vanilla extract from green vanilla beans using a β-glucosidase from Alicyclobacillus acidiphilus”
Last in the trilogy of Lidia’s PhD, lovely work completed with the help of Chris where a very rare green vanilla pod was used as the substrate! The paper was accepted just before Lidia’s Phd viva, a good sign! Read the full paper here Related Posts